Levofloxacin-induced Fixed Drug Eruption: A Case Report.
- Author:
Sung Soo HAN
1
;
Eui Hyun OH
;
Hyoung Il KWON
;
Joo Yeon KO
;
Young Suck RO
;
Jeong Eun KIM
Author Information
1. Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea. dermakim@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Fixed drug eruption;
Levofloxacin
- MeSH:
Analgesics;
Anticonvulsants;
Drug Eruptions*;
Female;
Fluoroquinolones;
Forearm;
Humans;
Hypersensitivity;
Hypnotics and Sedatives;
Intradermal Tests;
Levofloxacin;
Middle Aged;
Patch Tests;
Recurrence;
Sulfonamides;
Tetracycline
- From:Korean Journal of Dermatology
2017;55(7):445-448
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fixed drug eruptions (FDEs) are characterized by the presence of site-specific recurrence of a solitary or multiple, well-circumscribed, erythematous macules or patches that recur with each exposure to a particular medication. Several drugs including non-steroidal anti-inflammatory drugs, non-opioid analgesics, sedatives, anticonvulsants, sulfonamides, and tetracycline have been associated with an increased risk of inducing FDE. A 45-year-old woman with known history of levofloxacin use presented with erythematous patches on her face and left forearm. Although a patch test to levofloxacin showed a negative reaction, intradermal tests to assess hypersensitivity to levofloxacin were positive, and she was diagnosed with levofloxacin-induced FDE. Her antibiotic was switched to moxifloxacin, which she tolerated well. Moxifloxacin did not show cross-reactivity. Because of the widespread use of fluoroquinolones, it is important to consider these as possible etiological agents in cases of FDE. We describe a case of FDE diagnosed using positive intradermal tests to detect sensitivity to levofloxacin.
