Clinical trial of seculin combined with famciclovir in the treatment of herpes zoster neuralgia
10.13699/j.cnki.1001-6821.2016.13.001
- VernacularTitle:舍曲林联合泛昔洛韦治疗带状疱疹神经痛的临床研究
- Author:
Zhi-Bing PI
1
;
Hai LIN
;
Yu PENG
;
Yuan JIN
Author Information
1. 温州医科大学 附属第一医院 疼痛科
- Keywords:
seculin;
famciclovir;
herpes zoster neuralgia
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(13):1155-1157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of sertraline combined with famciclovir in treatment of herpes zoster neuralgia . Methods Ninety -four patients with herpes zoster neuralgia were randomly divided into treatment group and control group , 47 cases in each group. Two groups of patients were performed conventional nutritional and physical therapy . Control group was treated with oral administration of famciclovir 0.25 g, tid, treatment group added sertraline 50 mg? d-1 on the basis of control group . The course of treatment was 4 weeks. The visual analogues scale ( VAS ) , clinical efficacy , quality of life and the adverse drug reactions were compared between the two groups.Results In the treatment group , the VAS in 1 and 4 weeks were ( 5.13 ±1.26 ), (3.27 ±1.02), significantly decreased than before treatment ( P<0.05 ) , and significantly lower than control group, which were(6.17 ±1.57) and (4.87 ±1.13).The total effective rate in treatment group ( 93.62%) was higher than control group ( 74.47%, P <0.05 ) .The quality of life in two groups were significantly increased after treatment ( P<0.05 ) , and treatment group significantly higher control group (P<0.05).No serious adverse drug reaction was found in two groups.Conclusion The clinical efficacy of seculin combined with famciclovir in the treatment of herpes zoster neuralgia is significant.
