Research advance in the expression and mechanism of long non-coding RNA -steroid receptor RNA activator in breast cancer
10.13699/j.cnki.1001-6821.2016.12.028
- VernacularTitle:长链非编码 RNA类固醇受体 RNA激活子在乳腺癌中的表达及作用机制研究状况
- Author:
Chan LIU
1
;
Ya-Ning SHI
;
Neng ZHU
;
Ke DU
;
Ya-Guang NI
;
Duan-Fang LIAO
;
Li QIN
Author Information
1. 南华大学 药物药理研究所
- Keywords:
long non -coding RNAs;
steroid receptor RNA activator;
breast cancer
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(12):1147-1149
- CountryChina
- Language:Chinese
-
Abstract:
Steroid receptor RNA activator ( SRA) is a type of long non-coding RNA ( lncRNA ).The abnormal transcription of lncRNA -SRA were detected in the uterine , ovarian and breast , and the lncRNA-SRA level in breast cancer is higher than that of general population.LncRNA-SRA expression may serve as a new prognostic marker for patients with ER-positive breast cancers.Thus, elucidating the molecular mecha-nisms of lncRNA -SRA is important to develop novel proper strategies using target lncRNA -SRA in the diagnosis and treatment of breast cancer.
