Study on catabolism and clearance of enalapril maleate tablets in vivo tracked by surface-enhanced Raman scattering spectrometry
10.13699/j.cnki.1001-6821.2016.12.020
- VernacularTitle:表面增强拉曼光谱法跟踪分析马来酸依那普利片体内代谢消除的研究
- Author:
Sheng GAN
1
;
Qing-Niao LAI
;
Xiao-Guang SHI
;
Ting HAN
;
Chao-Quan WU
Author Information
1. 广西壮族自治区食品药品检验所
- Keywords:
enalapril maleate;
pre -processing;
catabolism tracking;
surface-enhanced Raman scattering spectrometry
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(12):1132-1135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To track the catabolic route and clearance of ena-lapril maleate tablets in vivo by surface -enhanced Raman scattering spectrometry , and put forward proposal to its safe medication.Methods The urine and feces of 15 patient exemplars was collected , pre-processed , blended with an equal volume of surface -enhancer , and tested at the identified peak of enalapril maleate of (1470 ±2 ) /cm.Then the clearance of active pharmaceutical ingredient was calculated and analyzed .Results The methodical recovery was high and the relevant standard deviation was within 3%.The active pharmaceutical ingredient was in good linear at the concentration of 5~100μg· mL-1 in urine and in feces, and the limit of detection was 0.5 μg · mL-1 and 1.3μg· mL-1 , respectively.Enalapril was effective to 11 exemplars, while its clinical effect was not responded on 4 exemplars.Conclusion The method is proved to be prompt and rapid , appropriate to the catabolic analysis in vivo and clinical evaluation to angiotensin -converting -enzyme Ⅰinhibitors.
