Clinical study of methimazole treatment of hyperthyroidism before menopause and its effect on immune functions
10.13699/j.cnki.1001-6821.2016.12.012
- VernacularTitle:甲巯咪唑治疗绝经前甲状腺功能亢进的临床研究及其对免疫功能的影响
- Author:
Dao-Liang QU
1
;
Zuo-Ming YANG
Author Information
1. 海南农垦那大医院 内科
- Keywords:
methimazole;
menopause;
hyperthyroidism;
regulatory T cells;
cytokines
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(12):1094-1097
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the safety of methimazole in the treat-ment of hyperthyroidism before menopause and its effect on regulatory T cells( Treg) , cytokines of CD4 +CD25 +.Methods A total of 164 pa-tients with hyperthyroidism were randomly divided into treatment group and control group , 82 cases in each group.Patients in treatment group were orally given methimazole 10 mg, tid, after 30 d reduced to bid, 10 mg each time, after another 15 d, reduced to qd, 15 mg each time.Pa-tients in control group were orally given propylthiouracil 100 mg, tid, af-ter 30 d reduced to bid, 100 mg each time, after another 15 d, reduced to tid, 50 mg each time.All patients were treated for 3 months.The thy-roid serological index , CD4 +CD25 + regulation T cells and cytokines levels between the two groups before and after treatment were compared.The incidences of adverse drug reactions in two groups were also observed.Results The thyroid stimulating hormone ( TSH ) , thyrotrophin receptor antibody ( TRAb ) significantly increased in two group ( P <0.05 ).The free triiodothyronine (FT3), free thyroxin(FT4) and thyroid peroxidase antibody(TPOAb) in two groups were significantly decreased.The TSH, FT3 ,and FT4 were improved more significantly in treatment group ( P<0.05 ).There was no significant change in the number of CD4 +T cells in the two groups before and after treatment (P>0.05).The number of CD4 +CD25 +Tregs cells, IL-6 and IL-10 levels significantly decreased , and treatment group were significantly lower than control group ( P<0.05 ).The incidence of adverse reactions was 2.4% in treatment group , 6.1% in control group ( P>0.05 ).The total effective rate of treatment group was 97.6%, significantly higher than 81.7% in control group ( P<0.05 ).Conclusion Compared with propylthiouracil , methimazole had better effect on thyroid hormone level and immune function in premenopausal hyperthyroidism patients.
