Clinical trial of quetiapine combined with valproate in the treatment of bipolar disorder
10.13699/j.cnki.1001-6821.2016.12.007
- VernacularTitle:喹硫平联合丙戊酸镁治疗双相情感障碍的临床研究
- Author:
Jun-Mei YU
1
;
Feng-Feng BAI
Author Information
1. 天津市安定医院 药剂科
- Keywords:
quetiapine;
valproate;
bipolar disorder;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(12):1078-1080,1084
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of quetiapine combined with valproate in the treatment of bipolar disorder.Methods Ninety-four patients of bipolar disorder were randomly divi-ded into control group ( n=47 ) and treatment group ( n=47 ).Control group was given oral valproate 500 mg, qd, and according to the tole-rance of the patients increased the dose of 750 mg, qd after one week.Treatment group was based on the treatment of control group , and re-ceived oral quetiapine 100 mg, qd for starting dose , then increased the dosage 100 mg daily in day 1-4, to 600 mg in day 5-7, to 800 mg, qd in day 8-28.Two groups were treated for 28 d.The clinical efficacy , serum total bilirubin ( TBIL ) , albumin , levels of inflammatory factors , quality of living evaluation , Bech -Rafaelsen mania scale ( BRMS ) , Hamilton depression scare(HAMD) scores and the safety were compared between two groups.Results After treatment , there were no significant difference in clinical efficacy between two groups ( P >0.05 ).After treatment, the levels of TBIL and albumin were significantly higher than those of control group ( P <0.05 ) , the levels of interleukin -1βand interleukin-4 in treatment group were significantly lower than those in control group ( P <0.05 ).The BRMS and HAMD scores in treatment group were significantly lower than those in control group ( P <0.05 ) . There was no significant difference in the incidence of adverse drug reactions between two groups ( P >0.05 ).Conclusion Quetiapine combined with valproate have a definite clinical efficacy and safety in the treatment of bipolar disorder, which can significantly improve the quality of life and reduce the manic and depressive symptoms.
