Clinical trial of clopidogrel combined with alprostadil in the treatment of cerebral infarction induced by middle cerebral artery stenosis
10.13699/j.cnki.1001-6821.2016.12.002
- VernacularTitle:氯吡格雷联合前列地尔治疗大脑中动脉狭窄致脑梗死的临床研究
- Author:
Li-Na YU
1
;
Jin-Xiang LIU
;
Gang-Ming XI
Author Information
1. 上海市徐汇区中心医院 神经内科
- Keywords:
clopidogrel;
alprostadil;
middle artery stenosis;
cerebral infarction
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(12):1063-1065
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of clopidogrel combined alprostadil in the treatment of cerebral infarction in-duced by middle cerebral artery stenosis.Methods A total of 108 cere-bral infarction patients were collected in this study.Fifty-four patients in control group were treated with routine therapy and aspirin 100 mg, qd for 14 d.And 54 patients in treatment group were treated with the routine treatment and clopidogrel 75 mg combined with alprostadil injection 10μL,qd for 14 d.The National institute of health stroke scale ( NIHSS ) and activity of daily life ( ADL) score were used to evaluate the recovery of two groups after 7 , 14 d.The hemorheology indexes including the whole blood viscosity , plasma fibrinogen and platelet adhesion rate after 14 d treatment were determined , and the adverse reactions were recorded in two groups.Results After treatment , the symptoms of patients in two groups were significantly improved compared with those before treatment ( P<0.05 ).The NIHSS and ADL scores of patients in treatment group were significantly better than those in control group (P<0.05).The total efficiency of treatment group (94.4%) was significantly higher than that of control group (79.6%,P<0.05).The recovery rate in treatment group(27.8%)was significantly higher than that in control group ( 11.1%, P<0.05 ).Hemorheology index showed that the recovery of patients in treatment group were significantly better than that in control group ( P<0.05 ).The incidence of adverse reactions in two groups had no significant difference ( P>0.05 ).Conclusion Clopidogrel combined with alprostadil is good to treat the acute cerebral infarction caused by middle cerebral artery stenosis , which can effectively improve the neural function recovery and the hemorheology indexes without the increase of the incidence of adverse reactions .
