Investigation and countermeasure research of off -label use of drugs in Chinese hospital
10.13699/j.cnki.1001-6821.2016.08.028
- VernacularTitle:中国医院超说明书用药调查与对策研究
- Author:
Yi-Yin HAN
1
;
Bei XU
;
Sheng-Hui MEI
;
Wen-Jing QI
;
Fang CHENG
;
Hui-Di DENG
;
Zhi-Gang ZHAO
Author Information
1. 首都医科大学 附属北京天坛医院 药剂科
- Keywords:
Chinese hospital;
off -label drug usage;
questionnaire survey;
countermeasure research
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(8):756-758
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the baseline data on off -label medication specification for clinical doctors or management department in hospitals.Methods Random questionnaire survey was implemented on various grades medical workers in hospitals by the conference, E-mail and web network.The usage practices of domestic off -label medicine were collected and analyzed.Results Totally 756 cases of off -label usage on 405 drugs from 1163 hospitals (617 tertiary referral center, 463 secondary, 83 primary) were investigated.Among the investigated hospi-tals, 71.88%hospitals allow the off-label usage, only 32.07%hospi-tals established the off-label medicine manual management regulations. The tertiary referral center hospitals established the drug management sys-tem and the regular meeting on off-label medicine usage, while the sec-ondary and primary hospitals insufficient relevant practice, the difference between them have statistical significance (P<0.01).Relevant statisti-cal significance also existed in pharmacists with various background of professional qualifications and academic diplomas ( P <0.01 ) . Conclusion Standardizing the instructions on off -label medication management is urgent for domestic hospitals, especially for the secondary and below hospitals.It is necessary to established national level applica-tion guidelines or management specification on off-label drug usage.
