Dosing regimen selection for cefazolin sodium pentahydrate based on its pharmacokinetic/pharmacodynamic analysis
10.13699/j.cnki.1001-6821.2016.08.018
- VernacularTitle:抗菌药物药代动力学－药效学模型用于优化五水头孢唑林钠的给药方案
- Author:
Xiao-Hong CUI
1
;
De-Qiang LI
;
Shu-Yun WANG
;
Yang CHU
Author Information
1. 河北医科大学 第二医院 药学部
- Keywords:
cefazolin sodium pentahydrate;
Monte Carol simulation;
dosing regimen
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(8):730-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the rationality of the used dosage of cefazolin sodium pentahydrate in the treatment of infections.Methods The pharmacodynamic data ( MIC ) was obtained from the preclinical studies.The pharmacokinetic data from the phaseⅠclinical research tri-als and published protein binding were varied according to lognormal and uniform distributions.A Monte Carlo simulation (10,000 subjects) esti-mated the cumulative fraction of response ( CFR) at f%T>MIC=50%for intravenous cefazolin sodium pentahydrate 0.25-3.0 g every 6-24 h.Results With the dosage of CFR≥90% as the optimal dosage regi-men, the lowest dosage for treating common infection was 1.0 g bid, 0.75 g tid and 0.5 qid, respectively.Conclusion Based on its pharma-cokinetic/pharmacodynamic characteristics, safety and cost effect, the appropriate dosing regimen of cefazolin sodium pentahydrate injection was 1.5-2.0 g every 12 h for mild and moderate infection, for serious infec-tion the dose can increase to 3.0 g every 12 h or follow doctors’ advices.
