Effects of high fat and calories diet on pharmacokinetics of melatonin prolonged-release tablet in healthy Chinese subjects
10.13699/j.cnki.1001-6821.2016.08.007
- VernacularTitle:高脂高热量饮食对褪黑素缓释片在中国健康人体内药代动力学的影响
- Author:
Jie PAN
1
;
Quan-Ying ZHANG
;
Wen-Jia ZHOU
;
Meng WANG
;
Xi-Wei JI
Author Information
1. 苏州大学 附属第二医院 药剂科
- Keywords:
melatonin;
pharmacokinetics;
HPLC -MS/MS;
high fat and calories diet
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(8):693-695,713
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of high fat and calories diet on pharmacokinetics of melatonin prolonged -release tablet in healthy Chinese subjects.Methods Ten healthy subjects were randomly as-signed to receive single oral dose of melatonin prolonged-release tablet 2 mg after overnight fasting or breakfast by a randomized crossover design. Plasma concentrations of melatonin were measured by HPLC -MS/MS. The pharmacokinetic parameters were calculated, and the effect of the high fat and calories diet on the pharmacokinetics of melatonin was evalu-ated.Results Under fasted and fed conditions, the main pharmacoki-netic parameters of melatonin were as follows:Cmaxwere (1.40 ±0.68), (1.13 ±0.38)ng? mL-1, t1/2 were (2.53 ±1.10), (2.64 ±1.85)h, tmax were (1.28 ±0.85), (2.28 ±1.52)h, AUC0-10 h were (4.69 ±2.21), ( 4.09 ±1.58 ) ng? mL-1 ? h, AUC0-∞ were ( 4.98 ±2.45 ) , (4.32 ±1.64) ng? mL-1? h.Conclusion The absorption of melato-nin was reduced by food intake.
