Research progress of voriconazole pharmacokinetics based on gene polymorphisms
10.13699/j.cnki.1001-6821.2016.07.028
- VernacularTitle:基于基因多态性的伏立康唑药代动力学研究状况
- Author:
Bei-Bei SHAO
1
;
Ning-Min ZHAO
;
Hong-Fei DUAN
;
Qiao-Yan LI
;
Yong-Cheng MA
;
Hong-Wei ZHAO
;
Yu-Hua QIN
Author Information
1. 郑州大学 人民医院/河南省人民医院 药学部
- Keywords:
voriconazole;
gene polymorphisms;
pharmacokinetics;
personalized medicine
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(7):663-666
- CountryChina
- Language:Chinese
-
Abstract:
As one of the most commonly used antifungal agents in clini-cal, there is significant inter-individual variability and serious adverse reactions in voriconazole with the influence of gene polymorphisms and some other non-genetic factors.Then the traditional medication mode is not suitable for voriconazole any more.This review aims to summarize the research actuality of pharmacokinetics of voriconazole based on gene poly-morphisms.We hope it will be useful for clinical rational medication.
