Clinical efficacy of glimepiride combined with pioglitazone on glycemic control in type 2 diabetes patients
10.13699/j.cnki.1001-6821.2016.07.006
- VernacularTitle:格列美脲片联合吡格列酮治疗2型糖尿病患者的临床研究
- Author:
Si HA
1
;
Bang-Zhu MENG
;
Deligen BATU
Author Information
1. 内蒙古民族大学 附属医院 药物临床试验机构
- Keywords:
glimepiride;
pioglitazone;
type 2 diabetes mellitus;
early efficacy
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(7):594-596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of pioglitazone combined with glimepiride in treatment of type 2 diabetes mellitus.Methods A total of 100 patients with type 2 diabetes mellitus were ran-domly divided into treatment group( n=60) and control group( n=40).Patients in control group were treated with pioglitazone 15 mg per day be-fore breakfast.Patients in treatment group were treated with pioglitazone 15 mg, and glimepiride 1 mg per day before breakfast, if the blood glu-cose not controlled after 14 d, increase the dose to 2 mg.The blood glu-cose levels and adverse drug reactions of patients were recorded.The treatment lasted 28 d.Fasting plasma glucose, 2 h postprandial blood glucose, hemoglobin A1c(HbA1c) , fasting insulin and body mass index were determined and compared before and after treatment.Results The HbA1c, fasting glucose and fasting insulin were lower than those before treatment(P<0.05).The fasting insulin ,fasting glucose levels of treat-ment group were obviously lower than those of control group( P<0.05).Conclusion There was a good therapeutic effect for type 2 diabetes mellitus with pioglitazone combined with glimepiride, which can control blood sugar of patients fastly, safely and effectively.
