Salvianolate for treatment of angina:An overview of systematic reviews
10.13699/j.cnki.1001-6821.2016.06.026
- VernacularTitle:注射用丹参多酚酸盐治疗心绞痛的系统评价再评价
- Author:
Yue LIU
1
;
Ying-Ying YAN
;
Suo-Di ZHAI
Author Information
1. 北京大学第三医院药剂科
- Keywords:
salvianolate;
angina;
overview of systematic review;
Meta analysis
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(6):560-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of salvianolate injection for angina by overview of systematic reviews( SRs).Methods The Cochrane library, PubMed, EMbase, CBM, CNKI and Wanfang da-ta were searched from the inception to July 2015.According to the inclu-sion and exclusion criteria, articles for systematic reviews and Meta -analysis were selected.Extracted the trials of systematic reviews and then RevMan 5.3 was used to undertake Meta analysis.Results A total of 7 articles were included, and the scores of AMSTAR tool in 67 percent of articles were above 7.A total of 18 outcomes were included, the results of grading showed that 15 outcomes ( 83 percent ) were graded as low quality.A total of 33 trials involving 3126 patients were overviewed.The results showed that:compared with the control group, salvianolate signifi-cantly increased the clinical efficacy ( P <0.001 ) and improved of electrocardiograph ( P<0.001 ) in treating unstable angina;and lowered the adverse drug reaction ( P <0.001 ).Conclusion Salvianolate is effective and safe for angina pectoris.Because of the poor methodological quality on the whole studies, high quality randomized controlled trials are required to provide reliable evidence.
