Clinical study of paclitaxel cisplatin chemotherapy combined with endoscopic mucosal dissection on the treatment of esophageal mucosal lesions
10.13699/j.cnki.1001-6821.2016.06.007
- VernacularTitle:紫杉醇顺铂化疗方案联合内镜下黏膜剥离术治疗食管黏膜病变的临床研究
- Author:
Chen HONG
1
;
Ye-Chun GU
Author Information
1. 浙江大学 附属第二医院 建德分院 消化内科
- Keywords:
mucous membrane of esophagus;
gastrointestinal motility;
endoscopic submucosal dissection
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(6):502-504
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of paclitaxel and plati-num chemotherapy combined with endoscopic mucosal dissection ( ESD) on esophageal mucosal lesions and its influence on the gastrointestinal dynamics.Methods A total of 80 cases of patients with esophageal mu-cosa lesions were divided into treatment group and control group,40 cases in each group.Treatment group was given paclitaxel 400 mg · m-2 , cisplatin 20 mg· m-2 chemotherapy combined with ESD at day 1, 8, 15, 22 , 29 , 36.Control group was given paclitaxel combined with cisplatin chemotherapy.The short -term efficacy, long -term efficacy and adverse drug reactions, the recovery time of bowel sounds, gastrointesti-nal peristalsis, anal exhaust and defecation function after treatment were compared between two groups.Results After treatment, the total effective rate of the treatment group was 80.00% ( 32/40 ) , which was significantly higher than that of control group 67.50% ( 27/40 ) ( P<0.05).The recovery time of bowel sound, gastrointestinal motility, anal exhaust and defecation in the treatment group were (53.14 ±3.18), (36.78 ±9.22 ) , ( 43.12 ±10.44 ) , ( 83.34 ±4.69 ) min, which were shorter than those of control group (75.21 ±3.77),(57.28 ±11.82),(63.82 ±10.28),(130.55 ±8.77) min(P <0.05).The total survival rate 70.00% (28/40), progression free survival (24/40), and local control rate 57.50%(23/40) in the treatment group were higher than 40.00%( 16/40 ) ,25.00%( 10/40 ) ,22.50%( 9/40 ) in control group ( P<0.05 ).Adverse drug reaction rates of the two groups had no significant difference (P>0.05).Conclusion For the patients with esophageal mucosal lesions the paclitaxel and cisplatin chemotherapy combined with ESD is better than the simple paclitaxel cisplatin chemotherapy, the recovery time of gastrointestinal motility is shorter, and the short and long-term effect is more obvious.
