Expression and comparison of significance of interleukin -17 in patients with chronic hepatitis B and hepatitis B virus cirrhosis
10.13699/j.cnki.1001-6821.2016.06.005
- VernacularTitle:白细胞介素－17在慢性乙型病毒性肝炎及肝硬化患者中的表达及意义比较
- Author:
Ji-Shun ZHENG
1
;
Meng-Meng CHEN
;
Xiang-Tian ZHOU
;
Yan-Yan LIU
;
Jia-Bin LI
Author Information
1. 安徽医科大学 第三附属医院 消化内科与感染科
- Keywords:
chronic hepatitis B;
hepatitis B virus cirrhosis;
interleukin-17;
hepatitis B virus DNA;
cytokine
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(6):495-498
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and compare the significance of interleukin-17 ( IL-17 ) A-F in patients with chronic hepatitis B ( CHB) and hepatitis B virus ( HBV) cirrhosis.Methods The stools and serum samples of 66 patients with CHB and 50 patients with HBV cirrhosis were collected, and the serum samples of 30 healthy volunteers were collected.HBV DNA in stool and serum were detected by real -time quantitative polymerase chain reaction ( PCR ) .IL-17A-F, IL-1β, IL-6 and CXC chemokine ligand 13 ( CXCL-13) were detected by ELISA.Liver function was detected by automatic bio-chemical analyzer.Results The expression of serum IL -17 A -F in patients with CHB or HBV cirrhosis were significantly higher than those in healthy volunteers ( P <0.01 ) , but no difference between patients with CHB and cirrhosis (P>0.05).In patients with CHB, IL-17A-F were positively correlated with IL-1β, IL-6 and CXCL-13, and ne-gatively correlated with total bilirubin.IL-17C was positively correlated with total bile acid.IL-17B, IL -17D and IL -17E were positivelycorrelated with stool HBV DNA.In patients with HBV cirrhosis, IL -17B was positively correlated with IL -1β.IL-17C was positively correlated with aspartate aminotransferase and alkaline phosphatase.IL-17D was positively correlated with alkaline phosphatase.IL -17 A -F had no correlation with serum HBV DNA and stool HBV DNA ( P>0.05) .Conclusion There were high expressions of serum IL -17A -F in patients with CHB and HBV cirrhosis, but the clinical significance of IL-17A-F was different.
