Clinical efficacy and safety of Danshen dripping pill combined with atorvastatin calcium in the treatment of type 2 diabetic mellitus with carotid atherosclerosis
10.13699/j.cnki.1001-6821.2016.06.003
- VernacularTitle:复方丹参滴丸联合阿托伐他汀钙治疗2型糖尿病合并颈动脉硬化的临床疗效及安全性评价
- Author:
Li SHI
1
;
Ming-Xia LI
;
Li-Kun WANG
;
Jun-Feng LIU
;
Gai-Jun NING
;
Wei-Dong REN
Author Information
1. 河北北方学院 附属第一医院 内分泌科
- Keywords:
Danshen dripping pill;
atorvastatin calcium;
type 2 diabetic mellitus;
carotid atherosclerosis;
endothelial function
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(6):489-491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of Dan-shen dripping pill combined with atorvastatin calcium in the treatment of type 2 diabetic mellitus with carotid atherosclerosis.Methods Ninety patients of type 2 diabetic mellitus with carotid atherosclerosis were randomly divided into control group ( n =40 ) and treatment group ( n=50 ).Patients in the control group were treated with atorvastatin cal-cium 10 mg, once per night for 3 months.Patients in the treatment group were treated with Danshen dripping pill 270 mg, tid combined with ator-vastatin calcium 10 mg, once per night for 3 months.The clinical effica-cy, blood lipid, vascular endothelial function, bilateral carotid intima-media thickness, plaque area, and adverse drug reactions were compared between two groups.Results After treatment, total effective rate in treatment group was significantly higher than that in control group (92.00% vs 82.50%, P<0.05 ).By comparison with control group, the blood lipid levels in treatment group was significantly lower, vascular endothelial function was improved, bilateral carotid plaque area and ca-rotid intima -media thickness were significantly lower ( P <0.05 ).There were no adverse drug reactions occurred between two groups during the treatment.Conclusion Danshen dripping pill combined withatorvastatin calcium can significantly decreases the level of blood-lipid, improve the symptom of carotid atherosclerosis and the endothelial function for the type 2 diabetic mellitus patients.
