Efficacy and safety of oxycodone hydrochloride for postoperative analgesia in spin surgery patients
10.13699/j.cnki.1001-6821.2016.05.009
- VernacularTitle:氨酚羟考酮用于脊柱手术后镇痛临床疗效及安全性评价
- Author:
Yun-Lin GE
1
;
Yi-Sheng LU
;
Chu-Di FU
;
Bing PAN
Author Information
1. 解放军第117医院 骨科
- Keywords:
spine surgery;
oxycodone hydrochloride;
morphine;
analgesia efficacy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(5):412-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of oxycodone hydrochloride for postoperative analgesia in patients who received spin surgery.Methods Sixty -nine patients treated with spin surgery were included in this study and randomly divided into treatment group ( n=34 ) and control group ( n=35).Half an hour before the end of operation ,the patients of the two group were given oxycodone hydrochloride and morphine 0.07 mg · kg-1 , respectively.After extubation , patient -controlled analgesia pump was given with the background dosage of 0.5 mg · h -1 and one time push 1 mg of oxycodone hydrochloride or morphine.The mean arterial pressure ( MAP) , and heart rate were com-pared in the time points of entering the operation room ( T0 ) ,tracheal in-tubation ( T1 ) , 5 min after tracheal intubation ( T2 ) , and 15 min after tra-cheal intubation(T3) between the two groups.The recovery time, extu-bation time ,visual analogue scale ( VAS) ,observer assessment of sedation ( OAA/S ) score and safety were compared between the two groups . Results The MAP and heart rate were not statistically different between the two groups and among the time points ( P>0.05 ).The recovery time , extubation time , VAS, OAA/S score in treatment group were significant lower than those of control group( P<0.05 ).The adverse drug reaction rates were 17.14%and 8.82% in the control group and treatment group respectively with statistical difference ( P<0.05 ).Conclusion Compared with morphine , oxycodone hydrochloride is more effective and safe for postoperative analgesia in patients who received spin surgery.
