Clinical efficacy and safety of butylphthalide in the treatment of patient with transient ischemic attack
10.13699/j.cnki.1001-6821.2016.05.007
- VernacularTitle:丁苯酞治疗高危性短暂性脑缺血发作的临床疗效与安全性
- Author:
Yan-Zhou QU
1
;
LJin
;
Li-Kang LAN
;
Qun GU
Author Information
1. 丽水市人民医院 神经内科
- Keywords:
transient ischemic attack;
butylphthalide;
clinical efficacy;
safety;
blood lipid
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(5):406-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of butylphthalide in the treatment of patient with transient ischemic attack.Methods Ninety -one cases with transient ischemic attack were ran-domly divided into control group ( n=45 ) and treatment group ( n=46 ).Patients in the control group were administered of ozagrel sodium 80 mg+0.9%NaCl 150 mL, ivgtt, bid; patients in treatment group adminis-tered of butylphthalide 25 mg, ivgtt, bid, two weeks a cycle.After 2 cycles treatment , the clinical efficacy of the two groups , the levels of serum fibrinogen(FIB) and triglyceride (TG) before and after treatment, the carotid intima-media thickness ( cIMT) and the area of the carotid artery, the area of the soft plaque and the incidence of adverse reactions were compared.Results Total clinical efficacy were 86.96%( 40/46 ) and 66.67%(30/45) respectively with statistical difference (P<0.05).The serum levels of TG and FIB were significantly decreased after treat-ment in both the control and treatment group ( P<0.05 ).The serum le-vels of TG and FIB were significant lower than control group after treat-ment ( P<0.05 ).Carotid artery IMT and plaque area in two groups had no significant changes of the two groups ( P >0.05 ).No significant adverse reaction in two groups occurred , only two patients with medication ncrease in transaminase , after 1 month, the aminotransferase levels recovery to normal.Conclusion Significant clini-cal efficacy and safety was found for butylphthalide in the treatment of transient ischemic attack.
