Influence of donor physiological condition on pharmacokinetics of mycophenolic acid and its metabolite in the early period after renal transplantation
10.13699/j.cnki.1001-6821.2016.05.006
- VernacularTitle:供体因素对肾移植术后早期霉酚酸及其代谢物药代动力学的影响
- Author:
Si LIU
1
;
Jia-Li LI
;
Long-Shan LIU
;
Shou-Ning ZHOU
;
Huan-Xi ZHANG
;
Chang-Xi WANG
;
Min HUANG
Author Information
1. 中山大学 药学院 临床药理研究所
- Keywords:
donor factors;
early period after renal transplantation;
mycophenolic acid;
pharmacokinetics
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(5):402-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of the physiological conditions and kidney function of the donors on their recipients ’ myco-phenolic acid ( MPA) and mycophenolic acid glucuronide ( MPAG) levels in the early period after renal transplantation.Methods Forty-two pa-tients receiving mycophenolate mofetil ( MMF) and 23 patients receiving enteric-coated mycophenolate sodium ( EC-MPS) , as well as their do-nors were included in this study.For patients who recieving MMF , MPA and MPAG concentrations were detected by HPLC , then AUCMPA and AUCMPAG were calculated by the limited sampling strategy (LSS) model es-tablished by our lab previously.For the patients receiving EC -MPS, AUCMPA and AUCMPAG were calculated by linear trapezoidal rule.Results Spearman test showed significant correlation between recipients ’ AUCMPAG and the age of donors in MMF group , EC-MPS group and the total cohort (P<0.05).Moreover, AUCMPAG in the recipients of elder group (>55 years old) was significantly higher than that in the younger group (≤55 years old) in both MMF group and the total cohort (P<0.05).In addition, AUCMPAG was siginificantly associated with the urea levels of donors before renal transplanta-tion in MMF group and the total cohort ( P<0.05 ).Patients were divided into tacrolimus ( FK506 ) or cyclosporin A ( CsA) group according to their comedication.AUCMPAG was significantly higher in CsA group than that in FK 506 group ( P<0.01 ).AUCMPAG in the recipients of elder group was significantly higher than that in the younger group ( P<0.05), and AUCMPAG was siginificantly associated with the urea levels of donors in FK 506 group (P<0.05).In CsA group, significant correlation between AUC MPAG and the age of donors was showed (P<0.05).Conclusion Our data suggested that the age and the urea level of donors might play roles in the recipients ’ MPAG exposure in the early period after renal transplantation .
