Effect of Xingnaojing Injection on nitric oxide, insulin-like growth factor-1 and macrophage inhibitory factor of hypertensive patients with intracerebral hemorrhage
10.13699/j.cnki.1001-6821.2016.05.005
- VernacularTitle:醒脑静注射液对高血压脑出血患者临床指标的影响
- Author:
Min-Feng TONG
1
;
Ji-Hong LIU
;
Hai-Bin DAI
Author Information
1. 金华市中心医院 神经外科
- Keywords:
Xingnaojing injection;
nitric oxide;
insulin -like growth factor -1;
migration inhibitory factor;
hypertensive intracerebral hemorrhage
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(5):399-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Xingnaojing Injection on nitric oxide(NO), insulin-like growth factor-1(IGF-1)and mac-rophage inhibitory factor ( MIF) of patients with hypertensive intracerebral hemorrhage .Methods One hundred forty cases of patients with cerebral hemorrhage diagnosis were chose from January 2012 to October 2014 in our hospital.They were randomly divided into control group (72 cases) and treatment group ( 68 cases ).The patients in the control group was conventional treatment and infusion of glucose injection.On this basis , the treatment group were treated with 30 mL Xingnaojing injection.The NO was detected by nitrate reductase method.The IGF-1 was detected by enzyme -linked immunosorbent assay and the MIF expression levels was detected by radioimmunoassay.The last of complications in patients was statistical analyzed.Results Treatment group total effective rate was 88.24%, significantly higher than 72.22% of patients in control group (P<0.05).NO levels in treatment group was (52.22 ±10.78)μmol· L-1, IGF-1 level was (61.90 ±10.94) nmol· L-1, NO and IGF -1 levels were significantly higher than in control group [(36.23 ±8.14)μmol· L-1 and (40.64 ±10.42)nmol· L-1].MIF levels in treatment group was (44.34 ±12.52)ng· L-1, significantly lower than in the control group of patients [ (56.92 ±11.36) ng· L-1 ] ( P<0.05).The complications number of patients in the treat-ment group was significantly lower than the control group patients (P<0.05).Conclusion Xingnaojing injection can not only improve patient outcomes , reduce postoperative complications in patients , can also increase the expression levels of serum IGF-1 and NO, reducing serum MIF levels , improve the condition of patients have significant role in promoting.
