Clinical efficacy and safety of peramivir trihydrate sodium chloride injection in the treatment of acute simple uncomplicated influenza
10.13699/j.cnki.1001-6821.2016.05.001
- VernacularTitle:帕拉米韦氯化钠注射液治疗无并发症的急性单纯性流行性感冒的临床疗效及安全性评价
- Author:
Xiao-Guang LI
1
;
Jie XU
;
Lu LI
;
Jing-Jin LIANG
;
Zhong-Hua DENG
;
Ying JIA
;
Fei LIN
;
Bi-Ying ZHANG
;
Yong-Feng KANG
Author Information
1. 北京大学 第三医院 感染疾病科
- Keywords:
peramivir;
influenza;
safety;
clinical efficacy
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(5):387-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of peramivir trihydrate sodium chloride injection in the treatment of acute simple uncomplicated influenza.Methods Accepting the 60 cases of in-fected patients as subjects.All patients were given a single intravenous infusion of peramivir sodium chloride injection 100 mL/0.3 g.Before treatment, 3 days and 7 days after treatment, all patients were inter-viewed 3 times and the subjects ’ symptoms and adverse events were eva-luated.Results Fever response rate was 100%, alleviate time was (23.40 ±13.43 ) h, other symptoms remission rate was 75% to 93%.Adverse events were given priority to the anomalies of laboratory tests , including elevated triglycerides in 11 cases, elevated alanine aminotrans in 1 case, QTc prolongation in 1 case, most of them returned to normal.No serious adverse events appeared.Conclusion Application of perami-vir sodium chloride injection in the treatment of acute simple uncompli-cated influenza is relatively safe and effective.
