Risk factors for hyperammonemia associated with valproic acid therapy in epileptic children
10.13699/j.cnki.1001-6821.2016.04.026
- VernacularTitle:丙戊酸治疗癫痫患儿诱发高氨血症的危险因素分析
- Author:
TI ZHANG
1
;
Shan-Sen XU
;
Fan YANG
;
Ya-Nan CHEN
;
Li-Mei ZHAO
Author Information
1. 中国医科大学 附属盛京医院 药学部
- Keywords:
valproic acid;
hyperammonemia;
epilepsy;
risk factor
- From:
The Chinese Journal of Clinical Pharmacology
2016;(4):363-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ammonia on liver function in children with epilepsy , and the risk factors of valproic acid ( VPA)-induced hyperammonemia.Methods The total of 236 cases of epileptic children with VPA monotherapy were divided into three groups, hyperammonemia group(HG, 40 cases), abnormal group(AG, 96 cases) and control group(CG, 100 cases).The K-nonparametric test for independent sample method was used to determine the correlation between the ammonia and the liver function of epileptic children.Logistic regression method was used to analyze the risk factors , such as age , gen-der, weight, dosage, concentration of VPA, of VPA induced to hyperam-monemia.Results Among the three groups , the liver function of 25 ca-ses(62.5%), 42 cases(43.8%), 43 cases(43.0%) were beyond the reference range respectively , and there were 5 cases ( 12.5%) , 7 cases (7.3%), 2 cases (2.0%) appeared liver injury respectively.The fre-quencies of epileptic children with liver injury in HG was significantly higher than that in AG and CG ( P<0.05 ).Logistic regression showed that age(small), the daily dose(big),the concentration of VPA (high) were the risk factors of VPA induced hyperammonemia.Conclusion When the epileptic children were treated with VPA mono-therapy , the concentration of ammonia in vivo should be concerned.We could adjust the dose and plasma concentration of VPA to avoid the occurrence of hyperammonemia in well -controlled children.
