Analysis on blood concentration monitoring of digoxin and influential factors in Peking university first hospital
10.13699/j.cnki.1001-6821.2016.04.025
- VernacularTitle:北京大学第一医院地高辛血药浓度监测与影响因素分析
- Author:
Shu-Qing CHEN
1
;
Zi-Kun WANG
;
Fan WU
;
Xia ZHAO
;
Wen-Hui DING
;
Yi-Min CUI
Author Information
1. 北京大学第一医院
- Keywords:
digoxin;
therapeutic drug monitoring;
administrating behavior
- From:
The Chinese Journal of Clinical Pharmacology
2016;(4):360-362
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the factors that may have impact on se-rum digoxin concentration ( SDC ) as well as its drug -drug interaction.Methods Using systematic method , gathering the inpatients′SDC of Peking university first hospital from January to December , 2014.Using retrospective method , statistics and analysis of the influence factors inclu-ding dosage, age, gender, therapeutic drug monitoring value ( TDM), creatinine clearance ( CrCl ) , electrolyte and co -administration of pa-tients in cardiovascular department were carried out.Results There are 49.8%of the patients with their SDCs below 0.5 ng · mL-1 , 24.1%of the SDCs in the range of 0.5-0.8 ng · mL-1 , 25.7% of the SDCs in the range of 0.8 -2.0 ng· mL-1 , 4.2% of the SDCs are over 2.0 ng· mL-1.The significant factors which influence SDC are age , CrCl and co -administration with antibiotics and nitrates ( P <0.05 ).Conclusion The usage of digoxin in Peking university first hospital is fairly reasonable , however the SDC is a bit of low for a large proportion of the patience.Digoxin dosage should be adjusted individually especially based on the patients ’ age , CrCl and drug combination in order to meet the future goal for achieving personalized medicine.
