Analysis of caspofungin combined with clindamycin for severe pneumocystis pneumonia

VernacularTitle:卡泊芬净联合克林霉素治疗重症肺孢子菌肺炎的案例分析
Author: Qing-Tao ZHOU ¹ ; Ning SHEN ; Meng WANG ; Li-Na SUN ; Yan-Ling DING ; Bei HE
Author Information

1. 北京大学第三医院呼吸内科
Keywords: pneumocystis; pneumonia; caspofungin; clindamycin
From: The Chinese Journal of Clinical Pharmacology 2016;(4):351-353
CountryChina
Language:Chinese
Abstract: Objective To investigate the therapeutic value of caspofun-gin combined with clindamycin for pneumocystis pneumonia ( PCP ).Methods The clinical data of two severe PCP patients treated by caspo-fungin combined with clindamycin regimen in department of respiratory medicine of our hospital were analyzed.Because of definitely sulfame-thoxazole/trimethoprim (SMZ/TMP) allergy history, they were both ini-tially treated with caspofungin single drug , and received mechanical ven-tilation and methylprednisolone treatment.However , clindamycin was added to both patients after 3-4 days because of poor response to caspo-fungin monotherapy.Then they got better gradually , the arterial blood gas and chest CT scan showed that the respiratory failure and lung infil-tration were much improved.Results and Conclusion The courses of caspofungin combined with clindamycin were both 3 weeks, the patients were cured without adverse drug reactions.For PCP patients with limited usage of SMZ/TMP, caspofungin combined with clindamycin may be an effective and safe regimen.