Association between HLA alleles and lamotrigine-induced cutaneous adverse drug reactions in the Uyghur population with epilepsy of Xinjiang region
10.13699/j.cnki.1001-6821.2016.04.012
- VernacularTitle:HLA 基因与新疆维吾尔族癫痫患者中拉莫三嗪所致药疹的关联性
- Author:
Yang GAO
1
;
Ai-Ping YU
;
Yu-Feng JIANG
;
Lu-Hai YU
;
Zong-Feng ZHAO
;
Yan-Jun ZHANG
Author Information
1. 安徽医科大学 新疆临床学院
- Keywords:
epilepsy;
aromatic antiepileptics drugs;
lamotrigine;
human leucocyte antigen;
maculopapular exanthema
- From:
The Chinese Journal of Clinical Pharmacology
2016;(4):324-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between HLA -A*3001 , HLA-A*3101 , HLA-B*1502 , HLA-B*38 , HLA-B*5801 alleles and lamotrigine -induced cutaneous adverse drug reactions in Xinjiang Uyghur epilepsy patients.Methods HLA-A*3001, HLA-A*3101, HLA-B*1502, HLA-B*38, HLA-B*5801 alleles genoty-ping was performed by a polymerase chain reaction -sequence specific primers ( PCR -SSP ) method in 28 subjects who had lamotrigine .10 Uyghur subjects had lamotrigine -induced maculopapular exanthema ( MPE) , 18 lamotrigine tolerant controls ) , and 30 healthy individuals , and the correlation between HLA genes and LTG -MPE was analyzed.Results There seemed to be no statistical differences in the positive frequency of subjects with the HLA -A*3001, HLA -A*3101, HLA-B*1502, HLA -B*38, HLA -B*5801 alleles between the LTG-MPE group and LTG-tolerant group, and normal group (P>0.05). Conclusion There seems to be no significant correlation between HLA -A*3001, HLA-A*3101, HLA-B*1502, HLA-B*38, HLA-B*5801 alleles and lamotrigine induced cutaneous adverse drug reactions .
