Relationship between the serum biomarkers levels and the carotid artery plaque in atherosclerotic cerebral infarction patients
10.13699/j.cnki.1001-6821.2016.04.010
- VernacularTitle:血清生物标志物水平与脑梗死伴颈动脉斑块形成的关系
- Author:
Ai-Xia SONG
1
;
Zheng-Yu SONG
;
Rong JI
;
Qian XUE
Author Information
1. 河北北方学院 附属第一医院 神经内科
- Keywords:
serum oxidized low density lipoprotein;
C-reactive protein;
matrix metalloproteinase -9;
carotid artery plaque
- From:
The Chinese Journal of Clinical Pharmacology
2016;(4):318-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of the levels of serum oxidized low density lipoprotein ( ox-LDL), C-reactive protein (CRP) and matrix metalloproteinase -9(MMP-9) with carotid artery plaque in atherosclerotic cerebral infarction patients.Methods One hundred -ten patients with atherosclerotic cerebral infarction ( ACI ) selected as the observation group , and 100 healthy subjects as control group were selected to detect the level of serum ox -LDL, CRP and MMP-9 by enzyme-linked immunosorbent assay and the ACI patients were measured by carotid artery ultrasound.Results The levels of serum ox-LDL, CRP, and MMP-9 in observation group were higher than those in control group [ ( 261.54 ±24.51 ) vs ( 146.51 ±19.59 )μg· mL-1;(4.54 ±1.21) vs (0.87 ±0.15) μg· mL-1;(139.76 ±41.22) vs (65.76 ±23.48 ) ng· mL-1 , and there was significantly different ( all P<0.01 ).The levels of serum ox -LDL, CRP, and MMP-9 in ACI patients with plaque were higher than those in ACI patients without plaque [(205.27 ±20.11) vs (162.50 ±19.71)μg· mL-1;(4.32 ±1.03) vs (1.21 ±0.10 ) μg· mL-1;(90.71 ±24.03 ) vs (71.71 ±23.21 ) ng· mL -1 , and there was significantly different ( P<0.01 ).Serum ox-LDL, CRP and MMP-9 levels were the independent risk factors for the formation of carotid plaques of ACI patients , and had significantly positive correlation.Conclusion The high level of serum ox -LDL, CRP, and MMP-9 are the independent risk factors for carotid plaques of ACI , which could be used as important reference indexes for diagnosis of the formation of carotid artery plaque on ACI patients.
