Evaluation of clinical curative effect and safety of dimemorfan phosphate in the treatment of dry cough
10.13699/j.cnki.1001-6821.2016.04.007
- VernacularTitle:磷酸二甲啡烷治疗干性咳嗽的临床疗效及安全性评价
- Author:
Yan-Wen CHEN
1
;
Zhao-Long CAO
;
Fei TANG
;
Ke-Xin CUI
;
Xin-Lin MU
;
Shuang LIU
;
Hao-Yan WANG
;
Xiao-Wen HAN
;
Hui-Ping LI
;
Xiao-Dong MEI
;
Ke-Fang LAI
;
Zhi-Qiang QIN
;
Yue-Jian LIU
;
Fa-Guang JIN
Author Information
1. 北京大学 人民医院 呼吸与危重症科
- Keywords:
dimemorfan phosphate;
dextromethorphan;
placebo;
dry cough;
clinical efficacy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2016;(4):309-311,326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of dimemorfan phosphate in the treatment of dry cough.Methods Three hundred seventy -eight patients with dry cough were randomly divided into experimental group ( n=216 ) , positive control ( n=108 ) and place-bo group ( n=54 ).Experimental group was taken dimemorfan phosphate 20 mg, orally, tid, 5 -7 d.Positive control group was taken dextro-methorphan 30 mg, orally, tid, 5 -7 d.Placebo group was taken dimemorfan phosphate simulation tablets 20 mg or dextromethorphan simulation tablets 30 mg, tid, 5-7 d.Comparison of the clinical effica-cy, change of the total cough score after 5-7 d treatment, and the inci-dence of adverse drug reactions between the three groups.Results The clinical effectiveness of cough symptom after treatment , experimental group and positive control group and placebo group were 81.02%, 84.26%and 38.89%, respectively.The difference between experimen-tal group with placebo group was statistically significant ( P <0.01 ) , there was no statistically significant difference between experimental group with positive control group ( P>0.05 ).The average decrease of total cough score after treatment in the experimental group , the positive control group and the placebo group were (2.34 ±1.42), (2.43 ±1.55) and (1.39 ±1.20), respectively.The decrease in the total cough score of experimen-tal group was superior to that of placebo group ( P<0.01 ) , the decrease in the total cough score of experimental group was not inferior to positive control group ( P>0.05 ).The incidence of adverse events were 4.21% in experimental group , 12.04%in positive control group and 5.66%in placebo group , respectively.Among these , the incidence of adverse events associated with drug were 1.87%, 10.19%, 5.66%, respectively.Conclusion Dimemorfan phos-phate has exact antitussive efficacy in the treatment of dry cough , has the same antitussive efficacy and similar side effect in the treatment of dry cough compared with the dextromethorphan.
