Clinical efficacy and safety of piperazine ferulate combined with irbesartan in the treatment of diabetic nephropathy
10.13699/j.cnki.1001-6821.2016.04.002
- VernacularTitle:阿魏酸哌嗪联合厄贝沙坦治疗糖尿病肾病的临床疗效及安全性评价
- Author:
Dong-Hong WEI
1
;
Gui-Dong ZHAO
;
Min YU
;
Bei JIANG
Author Information
1. 胜利石油管理局胜利医院
- Keywords:
piperazine ferulate;
irbesartan;
diabetic nephropathy;
renal function;
clinical efficacy;
safety
- From:
The Chinese Journal of Clinical Pharmacology
2016;(4):294-296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of piperazine ferulate combined with irbesartan in the treatment of diabetic nephropathy.Methods A total of 74 patients with diabetic nephropathy were randomly divided into treatment group ( n=37 ) and control group (n=37).Control group was received irbesartan 150 mg, once a day.Treatment group was given piperazine ferulate 150 mg, once a day on the basis of control group.The treatment course of two groups was 12 weeks.The clinical efficacy , serum creatinine , blood glucose , blood urea nitrogen, urinary albumin excretion rate , hemodynamic level and adverse drug reactions were compared between two groups.Results After treat-ment, total effective rate in treatment group was significantly higher than that in control group (94.59%vs 75.68%, P<0.05).After treatment, serum creatinine , urinary albumin excretion rate , hemodynamic level in treatment group were significantly better than those of control group ( P<0.05).The blood glucose and blood urea nitrogen in two group were no obvious change ( P>0.05 ).Patients in two groups showed dif-ferent degrees of nausea , vomiting, abdominal pain , dizziness and other symptoms , but after symptomatic treatment turn , they were got better.There were no statistical significance of the incidence of adverse drug reactions between two groups ( P>0.05 ).Conclusion Piperazine ferulate combined with irbesartan in the treatment of diabetic nephropathy patients was effective , which can improve the renal hemodynamics , protect the renal function , and reduce the proteinuria.
