Progress of glyburide transport mechanisms in the human placenta
10.13699/j.cnki.1001-6821.2016.03.028
- VernacularTitle:格列苯脲在人胎盘中转运机制的研究状况
- Author:
Wen-Jing DUANMU
1
;
Hua HUANG
;
Qin YAO
;
Jing-Jing WANG
;
Qiao-Ling ZHENG
;
Jun ZHANG
Author Information
1. 昆明医科大学 第一附属医院 临床药学科
- Keywords:
glyburide;
human placenta;
P-glycoprotein;
multidrug re-sistance-related protein;
breast cancer resistance protein;
organic anion transporting polypeptide 2B1
- From:
The Chinese Journal of Clinical Pharmacology
2016;(3):283-285
- CountryChina
- Language:Chinese
-
Abstract:
With the in-depth study of oral hypoglycemic drugs , the safe-ty and effectiveness of glyburide in the treatment of gestational diabetes has been confirmed.Related studies showed that glyburide had a lower placental transmission.And the studies about placental transport mecha-nisms showed that it might be associated with a variety of transport pro-teins, including ATP ( adenosine 5 ’ -triphosphate ) -binding cassette ( ABC ) transporters and organic anion transporting polypeptides ( OATPs).
