Safety of hemocoagulase agkistrodon on the hemostasis in patients undergoing orthopaedic surgery
10.13699/j.cnki.1001-6821.2016.03.025
- VernacularTitle:尖吻蝮蛇血凝酶在老年患者骨科手术中安全性评价
- Author:
Xiao-Qian LAN
1
;
Ling-Yue MA
;
Min LU
;
Xia ZHAO
;
Fei-Fei GAO
;
Ying ZHOU
;
Yi-Min CUI
Author Information
1. 北京大学 第一医院 药剂科
- Keywords:
hemocoagulase agkistrodon;
safety;
senile patients;
orthopaedic surgery
- From:
The Chinese Journal of Clinical Pharmacology
2016;(3):273-275,285
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety of hemocoagulage agkistro-don(HCA) in orthopaedic surgical patients .Methods A total of 200 hospitalized patients undergoing orthopaedic surgery in our hospital were assigned to two groups: the trial group ( 100 cases: adult group 56 and senile group 44 ) and the control group ( 100 cases: adult group 56 and senile group 44 ).The patients in the trial group were administered with HCA during or just before the surgery.The patients in the control group didn′t use any hemostatic.Then, the blood routine test , coagulation function ,hepatic and renal function within 6 days before the surgery and within 3 days after surgery were compared by ANOVA for repeated mea-surement.Results There was statistically significant difference on time effect in all indicators except for total bilirubin ( TBIL ).There was no statistically significant difference of group effect in all indicators except for total protein ( TP ) and albumin ( ALB ).And there was statistically significant difference on age effect in red blood cell (RBC), hemoglobin (Hb), platelet(PLT), TP, ALB, creatinine(Cr),UREA and prothrom-bin time ( PT).No interaction effect was found in time & group , time &age & group.Conclusion Using HCA during or just before the ortho-paedic surgery shows no significant influence on the blood routine test , liver function , renal function and coagulation function.The application of HCA during or just before the orthopaedic surgery is safe , and there is no significant difference between the adult group and the senile group in drug safety of HCA.
