Difference of efficacy, safety and pharmacokinetics of voriconazole in different age:A systematic review
10.13699/j.cnki.1001-6821.2016.03.021
- VernacularTitle:伏立康唑在不同年龄段使用中安全性和有效性以及药代动力学差异的系统评价
- Author:
Yi-Meng GUO
1
;
Lin-Na AN
;
Ken CHEN
;
Chao ZHANG
Author Information
1. 北京大学 第三医院 药剂科
- Keywords:
voriconazole;
paediatric;
safety;
effectiveness;
systematic review
- From:
The Chinese Journal of Clinical Pharmacology
2016;(3):261-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the difference of efficacy , safety and pharmacokinetics of voriconazole between paediatric and adult patients.Methods The databases of PubMed , EmBase , Coehrane Controlled Trials Register, CNKI, CBM, WanFang Database and Clinical Trials were retrieved from database establish time to March 2015.Data were ana-lyzed using RevMan 5.1 software.Results A total of 9 studies (n=314) were included.The results of Meta-analysis showed there was no statis-tical differences between pediatric and adults patients for the effective rate of treating infection, the success rate of target Ctrough, the incidence of liver toxicity , the incidence of abnormal visual , the incidence of neu-rotoxicity, AUC/Dose( iv) and Ctrough ( po) ( P >0.05 ).But significant difference was found in AUC/Dose(po),Cmax/Dose(iv),Cmax/Dose(po) and Ctrough ( iv) ( P<0.05 ).Conclusion The current evidence shows that after the paediatric patients taking the voriconazole , the efficacy and safety were similar or less than the teenages and adults , and the pharma-cokinetic difference between paediatric and adult was obvious.
