Correlation of the level of serum biomarkers with carotid plaque in cerebral infarction patients
10.13699/j.cnki.1001-6821.2016.03.001
- VernacularTitle:脑梗死患者血清生物标志物水平与颈动脉斑块的相关性研究
- Author:
Ai-Xia SONG
1
;
Rong JI
;
Jun-Feng LIU
;
Qian XUE
Author Information
1. 河北北方学院 附属第一医院
- Keywords:
cerebral infarction;
serum oxidized low density lipoprotein;
c-reactive protein;
carotid artery plaque;
correlation;
matrix metalloproteinase-9
- From:
The Chinese Journal of Clinical Pharmacology
2016;(3):195-197,201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of the levels of serum oxidized low density lipoprotein ( ox -LDL ) , C -reactive protein ( CRP) and matrix metalloproteinase -9 ( MMP -9 ) of atherosclerotic cerebral in infarction patients with the carotid intima -media thickness ( IMT) and the stability of plaque.Methods A total of 110 patients with atherosclerotic cerebral infarction (ACI, group A),90 patients with lacunar infarction ( LACI, group B ) and 100 healthy volunteers ( group C) were selected.The levels of serum ox -LDL,CRP and MMP-9 by enzyme linked immunosorbent assay (ELISA) were detected and the IMT and the plaque formation were measured.Results The serum ox-LDL, CRP,MMP-9,IMT and the detection rate of group A and B were signifi-cantly higher than those of group C ( P<0.05 );serum ox-LDL, CRP, MMP-9 , smoking were the independent risk factors of the formation of carotid plaque in cerebral infarction patients ( P<0.05 ).The levels of serum ox -LDL, CRP, MMP -9 in the cerebral infarction patients without plaque group , with stable plaque group and unstable plaque group increased in turn ( P<0.05 ).Conclusion The increased levels of serum ox -LDL, CRP, MMP -9 in cerebral infarction patients are closely related with the bodiness of carotid artery IMT , the formation of the plaque and the stability.
