Meta-analysis of methylenetetrahydrofolate reductase genetic polymorphisms and adverse drug reactions of methotrexate
10.13699/j.cnki.1001-6821.2016.02.028
- VernacularTitle:亚甲基四氢叶酸还原酶基因多态性与甲氨蝶呤不良反应关系的 Meta分析
- Author:
Lin HUANG
1
;
Zhi-Ying YU
;
Qun GU
;
Yuan-Yuan WU
;
Wan-Yu FENG
Author Information
1. 北京大学人民医院药剂科
- Keywords:
methylenetetrahydrofolate reductase;
genetic polymorphism;
methotrexate;
acute lymphoblastic leukemia
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):183-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between methyle-netetrahydrofolate reductase ( MTHFR ) genetic polymorphisms and ad-verse drug reactions of methotrexate ( MTX) chemotherapy for acute lym-phoblastic leukemia ( ALL ) in China.Methods The relevant data bases were searched and reviewed.Meta -analysis was performed by software of RevMan 5.3.Results Ten studies were included , and half of them only involved MTHFR C 677 T, and the others involved both.The meta-analysis showed thatcompared with 677 CT/TT, 677 CC had a low-er risk of erythra ( P<0.05 );there were no significant differences in the total adverse drug reactions and other types of adverse drug reaction;age had no effect on the relationship between MTHFR genetic polymorphisms and adverse reactions of MTX.There were no significant differences in the total adverse reactions and different types of adverse reaction between 1298 AA and 1298 AC/CC; 1298 AA had a lower risk of mucositis than 1298 AC/CC in pediatric ALL ( P<0.05 ).Conclusion MTHFR C677 T and A1298 C polymorphisms do not seem to be good markers of MTX -re-lated total adverse drug reactions , but may affect part types such as eryth-ra and mucositis in Chinese ALL.
