Relationship between the levels of ghrelin and leptin and the hypoalbuminemia of advanced gastric carcinoma
10.13699/j.cnki.1001-6821.2016.02.027
- VernacularTitle:生长激素释放肽和瘦素与进展期胃癌低蛋白血症的关系
- Author:
Hai-Peng WANG
1
;
Xi-Jia ZHU
;
Li-Lan WANG
;
Xiao-Lin TIAN
;
Yong-Ling HE
;
Ling-Kun PANG
;
Ling DAI
;
Xiao CHEN
Author Information
1. 桂林医学院 附属医院 胃肠外科
- Keywords:
advanced gastric carcinoma;
ghrelin;
leptin;
hypoalbuminemia
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):180-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relationship between the level of ghrelin and leptin of patients with gastric carcinoma and the hypoalbu-minemia of advanced gastric carcinoma , and its significance of clinical pathology as well.Methods Radioimmunoassay ( RIA ) and enzyme linked immunosorbent assay (ELISA) were used to determine the changes of the ghrelin and leptin level in 20 cases of normal healthy people and 120 patients with gastric cancer ( including 37 cases of hypoalbuminemia ( albumin<35 g· L-1 ) and 88 cases of normal protein people ( albumin≥35 g· L-1 ) , their expressions and the relevance of clinical pathology parameters were also detected.Results The ghrelin and leptin levels of patients with gastric carcinoma were significantly higher than those of nor-mal group (P<0.01), and the ghrelin and leptin levels of patients with the hypoalbuminemia were obviously higher than those of health subjects with normal protein.In addition, in patients with high content of ghrelin and leptin , the rate of patients with poorly differentiated carcinoma and lymph node metastasis was obviously increased.Conclusion The detec-tion of the changes of ghrelin and leptin levels will be of great significance in the diagnosis and prognosis of gastric carcinoma , which provides theoretical basis for the diagnosis and treatment of cancerous hypoalbuminemia .
