In vitro activate of fosfomycin combined with imipenem against carbapenem -resistant Enterobacteriaceae

VernacularTitle:磷霉素联合亚胺培南对碳青霉烯类耐药肠杆菌科细菌的体外抗菌活性研究
Author: Xue-Shen QIAN ¹ ; Wen-Ying XIA ; Ya-Ning MEI ; Gen-Yan LIU ; Bing GU
Author Information

1. 泰州市中医院检验科
Keywords: fosfomycin; imipenem; carbapenem -resistant Enterobacteri-aceae; combined chemosensitivity
From: The Chinese Journal of Clinical Pharmacology 2016;(2):156-158
CountryChina
Language:Chinese
Abstract: Objective To evaluate the combined antibacterial effect of fosfomycin and imipenem against 60 carbapenem-resistant Enterobacteri-aceae ( CRE ) in vitro.Methods Experiment was designed by the checkerboard method , the minimal inhibition concentrations of single antibacterial drug or the combination of fosfomycin and imipenem at dif-ferent concentrations against 60 CRE isolated from inpatients were evalua-ted through agar double dilution method synergy effect of combination was assessed by fractional inhibitory concentration index ( FIC ) .Results Compared with single-use, the minimal inhibitory concentra-tion of thecombination of fosfomycin and imipenem decreased ( P<0.01).The combination of fosfomycin and imipenem demonstrated 23.3%( 14/60 ) synergism , 35.0%( 21/60 ) partial synergism , 1.7%(1/60) additive, 40.0%( 24/60 ) indifference, no antagonism in our study.Conclusion Combination of fosfomycin and imipenem showed synergism or partial synergism against most CRE isolates.