Clinical effect of flurbiprofen axetil injection on preemptive and postoperative analgesia in orthopedic surgery patients
10.13699/j.cnki.1001-6821.2016.02.018
- VernacularTitle:氟比洛芬酯对骨科手术超前镇痛及术后镇痛的临床疗效评价
- Author:
Xiu-Mei JIA
1
;
Li-Qin LAN
;
Li-Gui TANG
Author Information
1. 瑞安市人民医院 护理部
- Keywords:
flurbiprofen axetil;
orthopedic surgery;
analgesia;
C reactive protein;
prostaglandin E2
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):150-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the analgesic effects of flurbiprofen axetil injection on orthopedic surgery patients.Methods Seventy-eight orthopedic surgery patients were randomly divided into control group ( n=39 ) and test group ( n=39 ).Patients in control group were given intravenous administration of parecoxib 20 mg at 15 min before anaesthe-sia induced by propofol 1-2 mg · kg -1 and maintained by isoflurane in operation; after operation , 60 mg of parecoxib dissolved in 100 mL 0.9%NaCl was intravenously dripped.Patients in test group were given the same treatment beside the 20 mg of parecoxib was changed to 50 mg of flurbiprofen axetil.Average artery pressure ( MAP ) and heart rate (HR), visual analogue score ( VAS), Ramsay sedation score ( RSS), levels of serum C reactive protein ( CRP ) , prostaglandin E 2 ( PGE2 ) and incidence of adverse drug reactions of the two groups were observed.Results The MAP and HR, VAS, RSS of two groups showed no statisti-cal significance expect the VAS at moment post surgery; the content of serum CRP in test group at postoperative 24 h was ( 16.77 ±5.52 ) mg · L-1 , significantly lower than that of control group of ( 20.68 ±7.76 ) mg · L-1 ( P<0.05 ); the PGE2 content in test group had no significant difference with control group ( 135.1 vs 141.6 pg · mL -1 , P >0.05 ).The incidence of adverse drug reaction in test group was significantly lower than that in control group (7.7%vs 20.5%, P<0.05 ).Conclusion Flurbiprofen axetil injection can reduce the stress reaction of orthopedic surgery patients , the incidence of side effect was also lower.
