Analysis of influence factors of the common adverse reactions after high -dose methotrexate chemotherapy
10.13699/j.cnki.1001-6821.2016.02.014
- VernacularTitle:甲氨蝶呤化疗常见不良反应的影响因素分析
- Author:
Yi-Rui WANG
1
;
Jie WANG
;
Lin-Na AN
;
Hong CAO
;
Yun WU
Author Information
1. 新疆医科大学第一附属医院
- Keywords:
hematologic malignancy;
high-dose methotrexate;
adverse reaction;
influence factor;
medication safety
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):138-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the influence factors of common adverse reactions after high -dose methotrexate chemotherapy , and to provide basis for safe and rational clinical use of methotrexate.Methods Treatment protocols were referred to collaborative group of adults acute lymphoblastic leukemia ( CALLG2008 ) protocol, diagnosis and treatment of childhood acute lymphoblastic leukemia recommenda-tions, Hyper -CVAD protocol , improvement Bonn protocol , BFM90 protocol.Basic information , blood routine and biochemistry tests , metho-trexate plasma concentration , MTHFR C677 T gene polymorphism detec-tion results , and adverse reactions during the chemotherapy were collect-ed, and then analyzed the impact of fixed effect factors on adverse reac-tions by non -conditional Logistic regression.Results A total of 112 cases of patients with lymphatic cancer were recruited.Mucosal lesions , bone marrow suppression and anemia were mainly adverse reactions.Occurrence of oral mucositis was affected by patients ’ gender , weight and MTHFR gene type , while the incidence of anemia and bone marrow suppression after chemotherapy was affected by patients ’ weight and MTHFR gene type.Conclusion The impact factors of adverse reactions in chemotherapy of high -dose methotrexate were complicated , conducting relevant researches on influence factors of adverse reactions can provide foundation for individualized chemotherapy of high -dose methotrexate.
