Gene reversal mechanism of Weifuchun combined with colloidal bismuth pectin on patients with precancerous lesion of gastric carcinoma
10.13699/j.cnki.1001-6821.2016.02.009
- VernacularTitle:胃复春联合胶体果胶铋对胃癌前病变基因的逆转性研究
- Author:
Bo ZHENG
1
;
Jian-Zhang WANG
;
Ji-Hua PEI
;
Guo-Gang LI
;
Zhan-Xiang XUE
Author Information
1. 温州医科大学 附属第二医院 消化内科
- Keywords:
Weifuchun;
colloidal bismuth pectin capsules;
Notch1;
β-chain protein;
phosphatase and tensin homolog deleted on chromosome ten
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):123-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect of Weifuchun combined with colloidal bismuth pectin capsules on Notch 1, β-catenin and phosphatase and tensin homolog deleted on chromosome ten ( PTEN) in patients with precancerous lesion of gastric carcinoma.Methods A total of 115 patients with precancerous lesion of gastric carcinoma were randomly divided into experiment group ( n =60 ) and control group (n=55).Patients in experiment group were given Weifuchun 1.44 g, colloidal bismuth pectin capsules 150 mg, 3 times a day, while patients in control group given omeprazole 20 mg, 2 times a day, and sucralfate 0.25 g, 3 times a day, all patients treated for 4 weeks.The expressions of Notch1, β-catenin and PTEN of the two groups were observed.Results After treatment , the total effective rate of experiment group (68.3%) was significantly higher than that of control group (43.6%, P<0.01 ).After treatment , the positive rates of Notch 1 ,β-catenin in experiment group were decreased compared with those before treatment , and experiment group significantly lower than those in control group (P<0.01).After treatment, the positive expression of PTEN in experi-ment group was improved significantly , and significantly higher than thatin control group ( P<0.05 ) .Conclusion Weifuchun combined with colloidal bismuth pectin capsules can reduce the expression of Notch1,β-catenin of patients with precancerous lesion of gastric carcinoma , and enhance the expression of PTEN, which also had significant effect on improving the therapeutic effect and safety of treatment.
