Clinical efficacy and safety of glyburide combined with insulin on patients with gestational diabetes mellitus
10.13699/j.cnki.1001-6821.2016.02.007
- VernacularTitle:格列苯脲联合胰岛素对妊娠糖尿病的临床疗效与安全性评价
- Author:
Xiao-Mei ZHOU
1
;
Xiao-Hong HE
;
Li NAN
Author Information
1. 杭州市妇产科医院药剂科
- Keywords:
glyburide;
insulin;
gestational diabetes mellitus;
hypoglycemia;
premature infant
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):117-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of glyburide combined with insulin on patients with gestational diabetes mel-litus.Methods Sixty patients were randomly divided into control group and treatment group , each group 30 cases.Patients in control group were treated with insulin , and patients in treatment group treated with gly-buride 2.5 mg· d-1 combined with insulin.Record the general informa-tion of all patents before treating, glycosylated hemoglobin ( HbA1c), dose of insulin and peripheral blood glucose at the time of 12 weeks after treatment, index at perinatal period and index of newborn period in both groups.Results Compared with control group , there was no significant different in HbA1c, peripheral blood glucose , pregnancy hypertension , premature rupture of membranes , hydramnios , prolonged labor , cesarean delivery , macrosomia , neonatal respiratory distress syndrome , hyperbil-irubinemia , admission to neonatal intensive care unit.The time of blood glucose up to standard in treatment group was (11.5 ±4.0 ) d, signifi-cantly longer than that in control group , which was (7.2 ±2.0 ) d.Dose of insulin in treatment group was ( 10.50 ±3.18 ) U · d-1 , lower than ( 30.25 ±3.28 ) U· d-1 in control group.The incidence of hypoglycemiaand premature infant in treatment group were 7%, 7%, significantly lower than 20%and 23% in control group ( P<0.05 ).Conclusion The treatment of glyburide combined with insulin on patients with gestational diabetes mellitus treated is a safe and effective method.
