Clinical effect of Jianpi tiaozhong powder in the treatment of children with functional dyspepsia and its influence on gastrointestinal motility
10.13699/j.cnki.1001-6821.2016.02.005
- VernacularTitle:健脾调中散对功能性消化不良患儿的临床疗效及胃肠动力作用研究
- Author:
Ling-Min HU
1
;
Ya-Min ZHOU
;
Xiao-Ping LIANG
;
Ji-Cheng XIE
;
Xia-Sang QIU
Author Information
1. 恩泽医疗集团 台州医院
- Keywords:
functional dyspepsia;
children;
Jianpi tiaozhong powder;
gastrointestinal motility
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):111-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect of Jianpi tiaozhong powder in the treatment of children with functional dyspepsia ( FD) and its effects on the gastric motility.Methods Ninety children with FD were randomly divided into treatment group and control group , 45 cases in each group.Children in treatment group were given Jianpi tiaozhong powder one hour after the breakfast and supper , 10 mL for five to nine years old children and 20 mL for ten to fourteen years old children.Meanwhile , children in control group were given domperidone syrup orally, the doses of 5-7, 8-10 and 11-14 years old children were 5, 7 and 10 mL, separately.After one -month treatment, the clinical symptoms, side effect, electrogastrogram(EGG), motilin(MOT), soma-tostatin(SS) and gastrin(GAS) were recorded and compared before and after treatment.Results After treatment , the total efficiency of treatment group was 86.67%, significantly higher than that in control group, which was 75.56%( P<0.05 ).Improvement of symptoms in treatment group was more significant than that in control group( P<0.05 ).The percents of normal rhythm before meal were significantly higher than before treatment ( P<0.05 ).The motilin and somatostatin in treatment group were ( 235.7 ±19.4 ) , ( 18.8 ±2.5 ) pg · mL-1 , significantly lower than those in control group , which were ( 267.3 ±17.2 ) , ( 20.3 ±1.4 ) pg · mL-1.Gastrin in treatment group and control group were (168.6 ±17.2), (142.8 ±11.4) pg· mL-1, respectively (P<0.05).The motilin, somatostatin and gastrin after treatment were comparable than those before treatment in two groups ( P <0.05 ).There was no adverse drug reaction in two groups.Conclusion Jianpi tiaozhong powder had precise efficacy and slight side effect on children with FD.
