Clinical effect of rivaroxaban and enoxaparin on the prevention of lower deep vein thrombosis after artificial knee joint replacement
10.13699/j.cnki.1001-6821.2016.02.004
- VernacularTitle:利伐沙班和依诺肝素预防人工膝关节置换术后下肢深静脉血栓的临床研究
- Author:
Jun-Nan CHEN
1
;
Yadav Kumar PRANESH
;
Ying TANG
;
Gang YI
;
Yuan-Yi ZHENG
;
Shi-Rong CHEN
Author Information
1. 重庆医科大学 附属第二医院
- Keywords:
rivaroxaban;
enoxaparin;
artificial knee joint replacement;
lower deep vein thrombosis
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):108-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of rivaroxaban and enoxaparin on the prevention of lower deep vein thrombosis after arti-ficial knee joint replacement.Methods A total of 120 patients who ex-perienced first artificial knee replacement surgery were divided into two groups.And 12 h after surgery , 60 patients in treatment group were gi-ven oral rivaroxaban 10 mg · d -1 , 60 patients in control group received subcutaneous enoxaparin heparin 4000 IU · d-1.The treatment of two groups all lasted for 14 d.The incidence of deep vein thrombosis , bleed-ing, complications and long -term efficacy of patients between groups were compared.Results There were no statistical difference between treatment group and control group in terms of activated partial thrombo-plastin time ( APTT ) , blood platelets count ( PLT ) and D -dimer ( all P>0.05 ) .The incidence rate of lower deep vein thrombosis in treatment group was 11.67%( 7/60 ) and control group 15.00%( 9/60 ) , they had no significant difference ( P>0.05 ).There were no statistical difference between two groups in postoperative drainage , total amount of blood transfusion and hemorrhagic index ( all P>0.05 ).The incidence rate of petechiae in treatment group was 23.33%(14/60), and 18.33(11/60) in control group (P>0.05).There were no sta-tistical difference between two groups in visual analogue scale ( VAS) pain scores and swollen knee at first three days and seven days after operation (all P>0.05).There were no statistical difference between two groups in knee mobility and keen society score ( KSS) function scores during the follow-up half a year after operation (all P>0.05).The knee mobility and KSS function scores during the follow-up one year after operation in treatment group were higher than that in control group ( all P <0.05 ).Conclusion Rivaroxaban and enoxaparin had equivalent efficacy on the prevention of venous thrombosis after artificial knee joint replacement surgery.However, the long-term clinical effect of rivaroxaban was better .
