Clinical effect and safety of salvia miltiorrhiza polyphenols in treatment of coronary atherosclerotic heart disease
10.13699/j.cnki.1001-6821.2016.02.003
- VernacularTitle:丹参多酚酸盐治疗冠心病的临床疗效及安全性
- Author:
Xun HE
1
;
LüShi-wen
;
Jia-Yi GUO
Author Information
1. 金华市中心医院 药学部
- Keywords:
coronary atherosclerotic heart disease;
salvia miltiorrhiza polyphenols;
angina
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):105-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effect and safety of salvia miltiorrhiza polyphenols in the treatment of coronary atherosclerotic heart disease.Methods Sixty -six patients with coronary atherosclerotic heart disease were randomly divided into experiment group ( n=32 ) and control group ( n=34 ).Patients in experiment group were treated with salvia miltiorrhiza polyphenols 200 mg+0.9%NaCl 250 mL, intravenous drip, qd for 2 weeks;patients in control group treated with salvia injec-tion 30 mL+0.9%NaCl 250 mL, intravenous drip, qd for 2 weeks.The total amount of exercise metabolic , exercise-induced angina onset time , exercise-induced low pressure of 1 mm ST-off time, angina attacks, clinical efficiency and adverse drug reaction of the two groups were observed.Results Total efficacy was 87.50% in experiment group , significantly higher than 61.76% in control group ( P <0.05 ).The clinical index of the two groups were significantly improved after treatment ( P <0.05 ).The dosage of nitroglycerin and incidence of angina pectoris in experiment were significant lower than those of control group ( P<0.05 ).The incidence rate of adverse reactions had no statisti-cal difference ( 6.25% vs 8.82%, P >0.05 ).Conclusion Salviamiltiorrhiza polyphenols in the treatment of coronary atherosclerotic heart disease was effective and safe , which can re-duce the angina attacks.
