Effect of amphotericin B combined with endoscopic surgery on inflammatory response and immune function in patients with fungal rhinosinusitis
10.13699/j.cnki.1001-6821.2016.02.002
- VernacularTitle:两性霉素B联合内镜手术对真菌性鼻－鼻窦炎患者炎症反应及免疫功能的影响
- Author:
L-Yuan YANG
1
;
Jiang-Ju HUANG
Author Information
1. 太原市妇幼保健院 耳鼻咽喉科
- Keywords:
amphotericin B;
endoscopic surgery;
fungal rhinosinusitis;
inflammatory response;
immune function
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):102-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of amphotericin B com-bined with endoscopic surgery on inflammatory response and immune function in patients with fungal rhinosinusitis ( FRS ).Methods One hundred and four cases of patients with FRS treated with amphotericin B combined with endoscopic surgery were selected as treatment group.And 104 cases of healthy volunteers were randomly selected as control group.Patients in treatment group were treated with 4μg· mL-1 amphotericin B for nasal wash , once every day for 4 weeks.Patients in control group received no surgery or treatment.In treatment group before and after surgery , serum interleukin 4 ( IL -4 ) , IL -6 , IL -12 , IL -17 , lipoprotein ( a ) [ Lp ( a ) ] , high -sensitivity C -reactive protein ( hs-CRP) , total lymphocyte count , CD3 +, CD4 +, CD8 +, CD19 +, immunoglobulin G ( IgG) and IgM levels were detected.Results After surgery , 96 cases in treatment group achieved cure ( 92.31%) , 8 cases had no effect ( 7.69%).In treatment group before surgery , serum IL-4, IL -6, IL -12,IL -17,Lp (a), hs -CRP levels were significantly higher than those in control group ( P<0.01 ).After surgery , IL-4 , IL-12 and hs -CRP in treatment group were significantly higher than those in control group ( P <0.01 ), and without significant difference in comparison of IL -6, IL -17 and Lp ( a ) ( P>0.05 ) .Before surgery , total lymphocyte count , CD3 +, CD4 +, CD8 +and IgG in treatment group were signifi-cantly lower than those in control group , while theses indexes significantly increased after surgery ( P<0.01 ) , but significantly lower than that in control group ( P<0.01 ).In comparison of CD19 +and IgM between the two groups , there was no significant difference ( P>0.05 ).Conclusion Amphotericin B combined with endoscopic surgery helped to improve inflammatory response and immune function in patients with FRS .
