Clinical effects of atorvastatin in patients with acute ischemic stroke
10.13699/j.cnki.1001-6821.2016.01.023
- VernacularTitle:阿托伐他汀在急性缺血性脑卒中患者中的临床研究
- Author:
Hong-Xia ZHOU
1
;
Xing-Yuan WANG
;
Li-Juan FAN
;
Shan-Jin YANG
;
Hong-Bing CAO
;
Zhan-Ao WU
Author Information
1. 中国人民解放军第三五九医院 内科
- Keywords:
acute ischemic stroke;
different dose;
atorvastatin;
clinical effect
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(1):72-74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effects of two doses of atorvastatin in patients with acute ischemic stroke .Methods A total of 128 patients with acute ischemic stroke were randomly divided into two groups ,64 cases in each group .The patients in atorvastatin 20 mg group were given atorvastatin 20 mg daily , and the patients of the atorvastatin 10 mg group were given atorvastatin 10 mg daily.The treatment lasted for six months.Blood lipid , nerve function defect grading , atherosclerotic plaque area and adverse drug reactions were observed before and after six months.Results The total effective rate in the atorvastatin 20 mg group (98.4%) was significantly higher than that in the atorvastatin 10 mg group (84.4%) (P<0.05).Blood lipid, nerve function defect grading and atherosclerotic plaque area were obviously improved in two groups (P<0.05), and the atorvastatin 20 mg group had a better improvement against the atorvastatin 10 mg group ( P <0.05 ) . The incidence of adverse drug reactions in two groups were 4.7%, no statistical signifi-cance (P>0.05).Conclusion Aatorvastatin 20 mg can better improve the clinical symptoms , blood lipid level as well as atherosclerotic plaque area in patients with acute ischemic stroke , accordingly improve the quality of life in those patients .
