Effect diammonium glycyrrhizinate on the promotion of alopecia mice's hair growth
10.13699/j.cnki.1001-6821.2016.01.018
- VernacularTitle:甘草酸二铵促进脱毛小鼠毛发生长的作用
- Author:
Jian-Hua ZHANG
1
;
LüPeng
;
Chun-Lin YANG
;
Jian-Bo JIN
;
Hong-Jiang XU
;
Hong-Bo WANG
;
Li-Ting CHEN
Author Information
1. 余姚市人民医院 药学部
- Keywords:
cyclophosphamide;
diammonium glycyrrhizinate;
alopecia;
hair growth
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(1):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different dose of diammonium glycyrrhizinate ( DG ) on alopecia mice hair growth . Methods Alopecia mouse model was established by using cyclophos-phamide .The 50 , 100 mg · kg -1 · d-1 DG and 100 mg · kg -1 · d -1 saline were fed separately in low-dose DG group , high-dose DG group and blank group , for 8 weeks after alopecia.Pathological changes of the hair follicle in alopecia area were observed by using HE staining and electron microscopy.Results Compared with the model group and the blank group , at each time point , it was remarkable difference in statistics of the number of hair follicle in high -dose DG group ( P <0.05 ) . Electron microscopy confirmed the degree of mitochondrion vague and vacuolar in remaining hair follicle cell in high -dose DG group were lighter than model group and the blank group after 8 weeks. Conclusion High-dose DG promotes hair growth by reducing the hair follicle cell damage.
