Study of cytochrome P450 2C9 gene polymorphism in healthy Chinese Korean
10.13699/j.cnki.1001-6821.2016.01.010
- VernacularTitle:细胞色素P4502 C9在中国朝鲜族健康人群的基因多态性分布研究
- Author:
Shuang LI
1
;
Xiu-Jun WU
;
Ti ZHANG
;
Mei LIU
;
Li-Mei ZHAO
Author Information
1. 中国医科大学 附属盛京医院 药学部
- Keywords:
cytochrome P450 2C9;
cytochrome P450 2C9*2;
cyto-chrome P450 2 C9*13;
polymorphism;
polymerase chain reaction -restriction fragment length polymorphism;
Korean
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(1):30-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the drug -metabolizing enzyme gene cytochrome P450 2C9 ( CYP2C9 ) distribution in Chinese Korean healthy population .Methods Two hundred healthy volunteers from Chi-nese Korean were recruited .A polymerase chain reaction -restriction fragment length polymorphism ( PCR-RFLP) method was developed to detect CYP2 C9*2 and *13 allele frequencies and compare genetic po-lymorphism differences with other ethnic groups from literatures .Results Six cases of CYP2C9 *1/*2 mutation individuals , 1 case of CYP2C9*2/*2 mutation individual and 1 case of CYP2C9*1/*13 mutated individuals in Korean health subjects were found in this study . The allele frequencies of CYP2C9*2 and *13 gene were 2.98% and 0.37%respectively.The results showed that there were similar ethnic in the distribution of CYP2C9 in Chinese Korean and Mongolian. Conclusion The results showed that Chinese Korean existed CYP 2C9 gene polymorphism distribution , and the distribution was similar to the Mongolian in Chifeng region .
