Issues about the rationality of subject selection of aspirin and proton pump inhibitor fixed dose combination

VernacularTitle:质子泵抑制剂和阿司匹林固定剂量复方制剂的立题合理性探讨
Author: Ying CHEN ¹ ; Tao WANG ; Shui-Qiang WANG
Author Information

1. 国家食品药品监督管理总局药品审评中心
Keywords: aspirin; proton pump inhibitor; fixed dose combination
From: The Chinese Journal of Clinical Pharmacology 2015;(24):2502-2506
CountryChina
Language:Chinese
Abstract: Aspirin decreases the risk of cardiovascular thrombotic events, however, one of the side-effects associated with this use is serious gas-trointestinal adverse events, which can be fatal.Proton pump inhibitor ( PPI) is used for healing of ulcers and prevention of non-steroidal anti-inflammatory drug -associated gastric ulcer. In this article, we discuss the issues about the rationality of subject selection of aspirin and PPI fixed dose combination.