Application of physiologically based pharmacokinetic models in the prediction of drug-drug interactions mediated by transporters

VernacularTitle:生理药代动力学模型在预测转运体介导药物相互作用中的应用
Author: Lin CHEN ¹ ; Xiao-Pei LIU ; Chun-Hua XIA ; Jin-Fang HU ; Yu-Qing XIONG
Author Information

1. 南昌大学临床药理研究所
Keywords: physiologically based pharmacokinetic; transporter; drug-drug interaction; predicition
From: The Chinese Journal of Clinical Pharmacology 2015;(24):2483-2485
CountryChina
Language:Chinese
Abstract: Physiologically based pharmacokinetic ( PBPK ) models are built using a mathematic framework which is similar to these classic phar-macokinetic ( PK ) models, and are parameterized based on known physiology knowledge, and comprise many compartments corresponding to different organs and tissues in the body, which are connected by flow rates that parallel the circulating blood system.The values of PBPK models are gradually appreciated in the industry of drug development, especially in the field of drug -drug interaction due to their robust ability to predict drugs’ kinetic process in vivo.Then some basic concepts, advantages over classic models and their applications in drug-drug interaction fields asso-ciated with transporters of PBPK models are reviewed in the next context.