Effect of diammonium glycyrrhizinate on the pharmacokinetic of simvastain
10.13699/j.cnki.1001-6821.2015.24.018
- VernacularTitle:甘草酸二铵对辛伐他汀的药代动力学研究
- Author:
Ying-Ying ZHANG
1
;
Xiu-Jun WU
Author Information
1. 辽宁中医药大学 附属医院 药剂科
- Keywords:
diammonium glycyrrhizinate;
simvastain;
pharmacokinetic;
rat
- From:
The Chinese Journal of Clinical Pharmacology
2015;(24):2427-2429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of diammonium glycyrrhizinate on the pharmacokinetic of simvastain in rats.Methods A parallel de-sign was applied in this study.12 male Wistar rats were randomly divided into 2 groups:control group and treatment group ( n=6).Rats in control group were given simvastain alone 40 mg? kg-1 , while those in the treat-ment group were given diammonium glycyrrhizinate 40 mg? kg -1 followed by intragastric administration of simvastain 40 mg? kg -1 .The plasma concentration of simvastain was determined by LC -MS/MS method. Pharmacokinetic parameters were compared between the two groups. Results The pharmacokinetic parameters of simvastain in control group and treatment group were as follow:Cmax were(148.7 ±37.6) and (221.8 ±61.8) ng?mL-1;AUC0-t were (916.9 ±177.8) and (1573.2 ±676.6) ng?mL-1?h;and CLz were (10.4 ±1.7) and (7.1 ±2.7) L? kg-1? h-1 , respectively. Compared with control group, Cmax and AUC0-t in treatment group increased by about 48% and 72%, respectively, while the CLz decreased by about 32%.There was a significant difference between the two groups ( P<0.05) . Conclusion Diammonium glycyrrhizinate affected the pharmacokinetics of simvastain in rats.
