Study on pharmacokinetics of cefbuperazone in Chinese healthy volunteers

VernacularTitle:注射用头孢拉宗在中国健康人体的药代动力学研究
Author: He-Kun MEI ¹ ; Jin WANG ; Rui WANG ; Nan BAI ; Bei-Bei LIANG ; Jiang CAO ; Ming-Jin TANG ; Ken WEN ; Xue-Wei JIANG ; Hui NIU ; Kai WANG
Author Information

1. 解放军总医院转化医学中心
Keywords: cefbuperazone; pharmacokinetic; high performance liquid chromatography; plasma concentration; urinary excretion rate
From: The Chinese Journal of Clinical Pharmacology 2015;(24):2417-2419
CountryChina
Language:Chinese
Abstract: Objective To evaluate the pharmacokinetics of cefbupera-zone in Chinese healthy volunteers.Methods The study was designed as an open, randomized, self-control study.12 subjects were received 1.0, 2.0, 3.0 g of cefbuperazone, respectively. Cefbuperazone was determined by high performance liquid chromatography. WinNonlin 5.2.1 software was used to calculate the pharmacokinetic parameters. Results Linear range of cefbuperazone was 2 -250 μg? mL-1 .The main pharmacokinetic parameters of three doses(1.0, 2.0, 3.0 g) of cefbu-perazone were as follows: Cmax were (81.74 ±15.95),(145.47 ±42.22), (198.16 ±36.03)μg? mL-1, tmax were (1.01 ±0.03),(1.02 ±0.04), (1.01 ±0.03), t1/2 were (1.80 ±0.30),(1.88 ±0.31),(1.74 ±0.27), AUC0-t were (136.37 ±43.31), (263.74 ±93.95), (335.76 ±68.47)μg? mL-1? h, respectively. Urinary recovery rate with 16 h was ( 45.24 ±17.50 )%, ( 48.27 ± 15.18 )%, ( 40.82 ± 14.24 )%. Conclusion The characteristic of cefbuperazone is linear.